Aberrant crypt foci in colorectal carcinogenesis. Cell and crypt dynamics
نویسندگان
چکیده
منابع مشابه
Histomorphology of aberrant crypt foci in colorectal carcinoma.
Colorectal carcinogenesis is a complex multistep process that includes changes in histomorphological appearance of the colonic mucosa and changes at molecular level. Aberrant crypt foci (ACF) was first described by Bird in 1987 on examination of methylene-blue-stained colonic mucosa of azoxymethane-treated mice under light microscopy. Since then ACF was considered as the earliest preneoplastic ...
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Quercetin inhibits proliferation of human gastric and colonic cancer cells in vitro by suppressing mitosis and increasing apoptosis. Quercetin might therefore act as an anticarcinogen in the alimentary tract, but previous findings have been inconsistent. We fed rats quercetin at dietary concentrations of 1, 5, 20, and 50 g/kg. At < or = 20 g/kg, we observed a statistically significant reduction...
متن کاملHomogenization Model for Aberrant Crypt Foci
Several explanations can be found in the literature about the origin of colorectal cancer. There is however some agreement on the fact that the carcinogenic process is a result of several genetic mutations of normal cells. The colon epithelium is characterized by millions of invaginations, very small cavities, called crypts, where most of the cellular activity occurs. It is consensual in the me...
متن کاملCorrespondence between flat aberrant crypt foci and mucin-depleted foci in rodent colon carcinogenesis.
BACKGROUND Flat aberrant crypt foci (flat ACF) and mucin-depleted foci (MDF) are preneoplastic lesions identified in the colon of carcinogen-treated rodents stained with methylene blue (MB) and high iron diamine-alcian blue (HID-AB), respectively. The correspondence between flat ACF and MDF in the same colon of Min mice treated with azoxymethane (AOM) and of F344 rats treated with 1,2-dimethylh...
متن کاملAn Homogenization Model for Aberrant Crypt Foci
Several explanations can be found in the literature on how colorectal cancer begins. There is however some agreement on the fact that its carcinogenic process is a result of several genetic mutations of normal cells. The colon epithelium is characterized by millions of invaginations, very small cavities, called crypts, where most of the cellular activity occurs. It is consensual in the medical ...
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ژورنال
عنوان ژورنال: Cell Proliferation
سال: 2000
ISSN: 0960-7722,1365-2184
DOI: 10.1046/j.1365-2184.2000.00159.x